Manual page
Documentation
VCF/BCF/BAM encryption
View the Project on GitHub samtools/bcftools
Download www.htslib.org
This page describes a proof of concept implementation of BGZF block-level encryption which works for VCF, BCF, BAM and in general anything compressed with bgzip. The key requirement is that 1) the files remain .tbi and .csi indexable and 2) no changes to existing tools relying on HTSlib are required.
For more please check this PDF presentation.